. Who among the following were awarded Nobel Prize in 1958 for One Gene One Enzyme Concept?

[A] Landsteiner & Weiner
[B] Avery, Mccleod and mc Carthy
[C] Jacob & Wollman
[D] George Beadle and Edward Tatum

The Nobel Committee has asked you to write a summary of the CRISPR technology and offer your advice to help determine whether any of the scientists involved in the discovery of CRISPR methodologies and its application should be recognized by being awarded a Nobel Prize in the coming year.

a) In your response to the Committee, provide a brief (200-word maximum) synopsis of the CRISPR technology and its potential value to society in a form understandable to an educated scientific audience.

b) Explain, in detail, what specific advice you would offer the Committee about whether to award a Prize and who should receive it ([Use the recent Perspectives article by Eric Lander (Cell, 2016) as a starting point for

your reply and explain, in detail, reasoning for your recommendations. Remember that no more than 3 individuals can be awarded a Nobel Prize in a given year for the same body of work].

c) The President's Council of Advisors on Science and Technology (PCAST) has asked you to opine about whether a moratorium should be considered before funding CRISPR projects for use in human cells. Briefly describe your view(s)

In the Avery, McCleod, and McCarty experiment, live or heat killed virulent S strain bacterial cells (kill mice) and avirulent R strain bacterial cells (do not kill mice) were mixed with each other and with various enzymes before injecting into mice. Which of the following combinations of treatments would result in a transformation event such that transformed bacteria generated after the mixing of these materials would kill mice when injected into them?

i. heat killed S bacteria + heat killed R bacteria + protease
ii. heat killed S bacteria + heat killed R bacteria + RNAse
iii. heat killed S bacteria + heat killed R bacteria + DNAse
iv. heat killed S bacteria + live R bacteria + protease
v. heat killed S bacteria + live R bacteria + RNAse
vi. heat killed S bacteria + live R bacteria + DNAse
vii. heat killed R bacteria + live S bacteria + protease
viii. heat killed R bacteria + live S bacteria + RNAse
ix. heat killed R bacteria + live S bacteria + DNAse

a.i, ii, iv, v, vii, viii

b.iv, v

c.iii, vi, ix

d.vii, viii

e.iv, v, vii, viii