Question

Consider the following mutations and, for each, explain whetheryou expect it to be

a) potentially promoting cancer

b) dominant or recessive

1) A mutation that destroys the active site of an enzymenecessary to promote cell cycle

2) A very premature STOP codon in a gene encoding a proteininvolved in the excision-repair mechanism

3) A point mutation that renders constitutively active one ofthe signaling proteins in the Ras pathway

4) A null mutation in a gene encoding an apoptotic(apoptosis-promoting) protein.