1. Which of the following first interacts with the signal sequence on proteins that are inserted into the membrane?
Choose one:
A. SecA
B. SRP
C. LepB
D. FtsY
E. SecYEG translocon
2. Which of the following functions are associated with SRP?
Choose one or more:
A.acting as a chaperone
B.stalling translation until ribosome brought to destination
C.targeting proteins for degradation
D.bringing ribosome to SecYEG translocon
E.bringing ribosome to FtsY
F.recognizing signal sequence
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1. Which of the following first interacts with the signal sequence on proteins that are inserted into the membrane?
Choose one:
A. SecA
B. SRP
C. LepB
D. FtsY
E. SecYEG translocon
2. Which of the following functions are associated with SRP?
Choose one or more:
A.acting as a chaperone
B.stalling translation until ribosome brought to destination
C.targeting proteins for degradation
D.bringing ribosome to SecYEG translocon
E.bringing ribosome to FtsY
F.recognizing signal sequence
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Related questions
Second messengers play an important role in cellcommunication.
Which of the following best describes their role?
None | ||
integrate, amplify and distribute messages throughout thecell | ||
Release messages to other cells? | ||
Receive information at the cell surface |
What is true of disulfide bonds?
a. | They often occur in the cytosol | |
b. | They are a noncovalent bond | |
c. | They are formed enzymatically in the ER | |
d. | They act as reducing agents | |
e. | they increase protein flexibility |
Which of the following is NOT an example of a cell communicationmolecule?
nucleases | ||
nitric oxide | ||
hormones | ||
kinases |
What is true of binding pockets?
a. | They only occur in the membrane | |
b. | They occur in unfolded proteins | |
c. | They contain electrostatic interactions | |
d. | They contain variable amino acids | |
e. |
What is true of cell signaling?
a. | Extracellular signals transduced by rectors always alter cellbehavior very quickly | |
b. | Some cells require cell signals just to survive | |
c. | Cell signals can be interpreted differently by differentcells | |
d. | B and C only | |
e. | All of the above (A, B and C) |
Histone tails can be modified to change the shape and"tightness" of the nucleosomes. Acetylated histones result in whicheffect?
Open DNA | ||
increased transcription | ||
closed DNA | ||
decreased transcription | ||
1+2 | ||
1+4 | ||
3+4 | ||
2+3 |
Shifting the two bound tRNA from the A and P sites to the E andP sites of the ribosome involves:
a. | The movement of the small ribosome subunit down the mRNAchain | |
b. | The degradation of the A site on ribosome | |
c. | The synthesis of the E site on the ribosome | |
d. | The movement of the large subunit relative to the smallsubunit | |
e. | All of the above |
Intracellular signaling pathways are awesome! What is the onething they can NOT do?
a. | relay the signal, to spread it through the cell | |
b. | nothing, they can communicate any cellular need | |
c. | distribute the signal to more than one effector protein | |
d. | integrate the signal from more than one cellular pathway | |
e. | Amplify the signal received, making the signal stronger |
Specificity of protein/protein and protein/DNA binding isdetermined by what?
Non-covalent bonds | ||
Hydrophobic interactions | ||
Covalent bonds | ||
shape of the binding site | ||
all of the above | ||
none of the above | ||
1,2,3 | ||
1,2,4 | ||
1,3,4 |
The coiling structure of the DNA into chromosomes is achieved bywhat?
alpha helix | ||
beta pleated sheets | ||
chaperone proteins | ||
DNA/Protein complexing |
Which regions (s) of the DNA are found in the final protein?
a. | poly-A tail | |
b. | A and B | |
c. | Exons | |
d. | UTRs | |
e. | Introns |
Metabolic processes can be turned "on" and "off" by chemicalmodifcation.
Which chemical modification do we associate with changing theactivity of an enzyme in a transient/non-permanent manner?
Phosphorylation | ||
Ubiquitination | ||
Methylation | ||
Acetylation |
DNA hybridization involves attaching a florescent dye towhat?
a. | Antibody | |
b. | Nuclear stain | |
c. | Probe DNA | |
d. | tRNA | |
e. | rRNA |
QUESTION 30
The function of centrosome is:
1. | Microtubule initiation and organization in animal cells | |
2. | Organization of thin filaments | |
3. | Depolymerization of microtubules | |
4. | Organization of intermediate filaments |
2.5 points
QUESTION 31
The destinations of proteins synthesized on "free" ribomsomes include:
1. | Endoplasmic reticulum | |
2. | Nucleus | |
3. | Mitochondria | |
4. | Lysosomes |
2.5 points
QUESTION 32
Microtubules can be assembled and disassembled quickly in response to the cellular changes is because:
1. | Cells synthesize tubulin proteins very fast. | |
2. | Cells can turn other cytoskeletal filaments into microtubules | |
3. | Microtubules have an instable plus end and microtubules are probably organized by weak non-covalent interactions | |
4. | The motor proteins of microtubules can organize the microtubules in response to the cellular changes |
2.5 points
QUESTION 33
Both signal recognition particle and a translocon in rough endoplasmic reticulum membrane can recognize and bind to the signal sequence of a secretory protein, so they play the exact same role during protein co-translational translocation.
True
False
2.5 points
QUESTION 34
Rough endoplasmic reticulum is so named is because:
1. | It has many proteins associated with its surface. | |
2. | It has ribosomes associated with its cytosolic surface. | |
3. | It is associated with nuclear membrane. | |
4. | It has vesicles budding off its surface. |
2.5 points
QUESTION 35
The membrane vesicles that transport materials between membrane compartments have a protein coat. The protein coat has similar functions in different vesicles. These functions include:
1. | Help the enclosed material fold correctly. | |
2. | Help degrade the protein in the vesicles | |
3. | Maintain the internal pH of the vesicles | |
4. | Function as mechanical device to form a vesicle and select the components to be carried by a vesicle. |
2.5 points
QUESTION 36
Lysosomes are important for:
1. | Receptor-mediated endocytosis. | |
2. | Breaking down foreign particles brought into the cells by endosomes | |
3. | Regulating the process of organelle turnover. | |
4. | Protein trafficking between membrane compartments |
2.5 points
QUESTION 37
Which of the following is correct about membrane biosynthesis?
1. | Membranes are synthesized in Golgi Complex. | |
2. | Membranes arise from preexisting endoplasmic reticulum membranes. | |
3. | Membranes are synthesized on ribosomes. | |
4. | Membranes of all organelles have the same composition of proteins and lipids, since they all originate from endoplasmic reticulum. |
2.5 points
QUESTION 38
During skeletal muscle contractions, the shortening of the muscle fibers is because of:
The shortening of the thin and thick myofilaments. | ||
The shortening of the cytoskeletal filaments. | ||
The kinesin proteins moving over microtubules. | ||
The actin and myosin filaments sliding over each other. |
2.5 points
QUESTION 39
The assembly and disassembly of microtubules is regulated by rate of growth and shrinkage of the plus end.
True
False
2.5 points
QUESTION 40
The functions of Golgi complex include:
1. | O-linked oligosaccharides and most of a cellรขยยs complex polysaccharides are assembled in Golgi complex | |
2. | Cis Golgi complex sorts proteins | |
3. | Trans Golgi complex segregates proteins in different types of vesicles for dilevery. | |
4. | N-linked oligosaccharides are further processed in Golgi complex |