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Molecular and Cell Biology
University of Toronto St. George
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Browse the full collection of course materials, past exams, study guides and class notes for BIO130H1 - Molecular and Cell Biology at University of Toronto St. George verified by …

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Kenneth Yip

Melody Neumann, Kenneth Yip

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BIO130H1 Lecture Notes - Lecture 1: Endoplasmic Reticulum, Endomembrane System, Bacteria

BIO130H1 Lecture 1: Lectures 1 & 2

BIO130H1 Lecture 2: Model Organisms, the Central Dogma & Nucleic Acids

Tree of life: phylogenetic tree used to look at evolutionary relationships, constructed based on rna gene sequences, tree changes using different seque

BIO130H1 Lecture Notes - Lecture 2: Adenine, Eukaryote, Pentose

BIO130H1 Lecture Notes - Lecture 3: Dna Replication, Protein Structure, Hydrophile

BIO130H1 Lecture Notes - Lecture 3: Google Images, Deoxyribonucleoside, Ribonucleoside

BIO130H1 Lecture Notes - Lecture 4: Alpha Helix, Coiled Coil, Opioid Peptide

Note: the order of the aa"s is just as important as their presence e. g. leu-enkephalin is a natural opioid peptide which down modulates the perception

BIO130H1 Lecture 5: The human genome, histones and packaging of DNA

Bio130h, lecture 5: the human genome, histones and packaging of dna. Only 1. 5 per cent of our genes encode proteins. Intronic sequences make up a big

BIO130H1 Lecture Notes - Lecture 5: Hybridization Probe, Rubber Band, Nucleoid

It"s divided into 50% unique sequences and 50% repeated sequences: only 1. 5% of the genome encodes proteins. Introns protein-coding regions: part of t

BIO130H1 Lecture 5: BIO130 Lecture 5 - Protein structures and genomes

BIO130H1 Lecture 6: Packaging of Nucleosomes & DNA Replication

Packaging of nucleosomes: cohesion is involved in forming chromatin loops, loops may be attached to a nuclear scaffold to enable increased compaction.

BIO130H1 Lecture Notes - Lecture 7: Okazaki Fragments, Phosphodiester Bond, Primase

BIO130H1 Lecture Notes - Lecture 8: Reverse Transcriptase, Telomerase, Dna Replication

Telomerase to the rescue: the repetitive sequence that is added to the 3" end of the parental strand is determined by the rna template in telomerase. I

BIO130H1 Lecture Notes - Lecture 9: Sigma Factor, Enzyme, Phosphodiester Bond

Generation of an rna transcript: template: single-stranded dna (ssdna, rna linked by phosphodiester bonds, polymerase facilitates the reaction to produ

BIO130H1 Lecture 10: Transcription Part II

BIO130H1 Lecture 11: Transcription Part II continued

BIO130H1 Lecture 12: Translation

Genetic code: ensuring fidelity: two sequential steps in ensuring fidelity, aminoacyl-trna synthetases, there is one a-trna for each amino acid, atp ne

BIO130H1 Lecture 15: Phospholipids, Fluid Mosaic Model of Membranes, Steroids & Cell Features

BIO130H1 Lecture Notes - Lecture 16: Cytosol, Lipid Bilayer, X-Ray Crystallography

Cystolic and exoplasmic face / leaflet of the lipid bilayer: golgi bulges out and forms a vesicle, the leaflets stay consistent (no flip-flopping, nucl

BIO130H1 Lecture Notes - Lecture 17: Resting Potential, Electrochemical Gradient, Passive Transport

Proteins involved in membrane transport: multipass transmembrane proteins, create a protein-lined path across cell membrane, transport polar and charge

BIO130H1 Lecture Notes - Lecture 18: Electrochemical Gradient, Symporter, Uniporter

BIO130H1 Lecture Notes - Lecture 19: Exocytosis, Endocytosis, Nucleolus

BIO130H1 Lecture Notes - Lecture 20: Nuclear Pore, Transmembrane Protein, Translocon

Internal signal sequence / internal start transfer sequence. Path of a transmembrane protein from translation to the plasma membrane: cytosol er, trans

BIO130H1 Lecture Notes - Lecture 21: Fluorescence Microscope, Intermediate Filament, Electron Microscope

3 types of filaments form the cytoskeleton: microfilaments, made of actin, diameter: 5-9nm, look like two smaller filaments twisted around each other.

BIO130H1 Lecture Notes - Lecture 22: Intermediate Filament, Axon Terminal, Endomembrane System

BIO130H1 Lecture Notes - Lecture 23: Keratin, Occludin, Adherens Junction

Types of junctions: anchoring junctions, occluding junctions, channel-forming junctions, signal-relaying junctions. All present in epithelial cells (fi

BIO130H1 Lecture Notes - Lecture 24: Basal Lamina, Connective Tissue, Plant Cell

BIO130H1 Lecture Notes - Lecture 25: Gene Duplication, G1 Phase, G2 Phase

The cell cycle: m phase, the nucleus and cytoplasm divide, mitosis, cytokinesis. Interphase: period between cell divisions, g1 phase, normal metabolism

BIO130H1 Lecture Notes - Lecture 26: Spindle Apparatus, Cell Division, Kinetochore

Metaphase: all chromosomes are aligned, on the metaphase plate, microtubules from opposite poles, are attached to kinetochores of sister chromatics, ki