A person without the allele for sickle cell anemia has children with a person who is a carrier for sickle cell anemia but doesn’t have the disease. What percentage of their children will have sickle cell anemia? What percentage of their children will be carriers for sickle cell anemia? Show your work with a Punnett square. You can copy/paste the blank table below or create a table in the submission box to complete the Punnett square.

1. Two persons with the sickle cell trait marry and want to have children, but concerned about them having sickle cell anemia. What is the probability of sickle cell anemia in their children? What proportion of their children would you expect to be carriers?

2. If a person with the sickle cell trait marries a person with a normal hemoglobin, what is the probability they will have a child with sickle cell anemia? What proportion of their children would you expect to be carriers?

You have a couple who are thinking of having children. The wife has A blood type and is a carrier for sickle cell anemia; her father had O blood type. The husband has B blood type and is a carrier for b-thallassemia; his mother had A blood type.

a) What is the probability that the couple has a son who is a carrier for sickle cell anemia and thallasemia?

b) What is the probability that the couple has a daughter who is NOT a carrier for either disease?

If both of John's parents are heterozygous for sickle cell anemia and Sarah's parents are AA and Aa what are the chances that John and Sarah's child will have Sickle Cell Anemia? (Sickle Cell Anemia is an autosomal recessive disease)