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13 Dec 2019

True or False

The immunoglobulin domain is a stable scaffold containing two antiparallel β- sheets upon which to display hypervariable loops.

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17 Dec 2019
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Related questions

27."The"crystal"structure"of"your"protein"reveals"a"central"β!sheet."Which"of"the"

following"statements"about"β!sheets"is"TRUE?"

a.""Amino"acid"side"chains"in"β!sheets"all"extend"out"on"one"side"of"the"β!sheet."

b.""β!sheets"have"a"straight"edge on"appearance."

c.""β!sheets"are"composed"of"β strands"running"in"only"an"antiparallel"direction."

d."Two"adjacent"β strands"in"a"β!sheet"will"fulfill"all"of"the"possible"hydrogen"bonds"

between"their"peptide"back"bone"atoms."

e.""None"of"the"above"statements"are"true."

While comparing two different protein-sequencing methods requiring minute amounts of protein, you established the amino acid sequence of the entire light chain of a purified immunoglobulin. From this sequence you will be able to determine [complete the sentence and assess the resulting statements (1-6) as either factually correct (= true) or incorrect (= false)]:

1. the isotype of the immunoglobulin.

2. whether the B cell that produced this antibody received T-cell help.

3. the specific variable gene fragment used to produce this chain.

4. the antigen specificity of the immunoglobulin.

5. the approximated strength of the immunoglobulin’s binding to different Fc receptors.

6. the molecular weight of the post-translationally unmodified light chain.

A research group has experimented with a polyethylene glycol (PEG)-based tissue-engineering scaffold. This scaffold was then modified with an RGD peptide sequence. In this experiment, the RGD sequence was synthesized in one of two forms:

a) RGD coupled to a large PEG spacer (MW = 3400 Da) and attachment site moiety (***),

or

b) RGD coupled to the attachment site moiety (***) with very small PEG spacer as shown below. (MW = 800 Da).

1) Now that you know the role of the RGD terminal sequence in cell adhesion, what is the role of the PEG chain? Why did the researchers try different PEG molecular weight?

2) Based on the different designs we have seen in class for hemocompatible surfaces (e.g., Carmeda and Trillium), which form of the RGD sequence peptide will yield the highest cell attachment per given number of peptides when attached to the polymer scaffold? Justify your answer

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