Question

1) Loss of troponin T from the thin filament will result inwhich of the following?

a) No crossbridge activity with increases incalcium

b) Contunially active crossbridge cycling in the absenceof calcium

c) Shorter thin filaments

d) Loss of tropomyosin

e) There is no effect on control ofcrossbridges

2) Blebbistatin is a newly identified small molecule inhuibitorof myosin heavy chain. Scientists determined that it binds to themyosin-ADP-Pi complex with high affinity and inhibits ADP-Pirelease. What step of cross bridge function is affected?

a) ATP binding to the myosin head

b) Myosin binding to actin

c) Release of bound myosin from actin

d) cross bridge movement

e) It causes rigor mortis.

3) The muscle contraction with the highest maximum velocity ofshortening occurs under what conditions?

a) Only when lifting the heaviest load

b) Only in the shortest muscles

c) Only in the muscles with the highest number ofmitochondria

d) Only under unloaded conditions

e) Only in the hamstring muscles

4) There is a disease in which skeletal muscle cannot storeglycogen. What would you predict as an outcome?

a) Increased muscular endurance

b) Less reliance on the liver for glucose duringcontractions

c) More reliance on the liver for glucose duringcontractions

d) Increased muscle strength

e) Changes in the length: tensionrelationship

5) Caffeine is a known agonist of the ryanodine receptor inmuscle. If you put caffeine on a single muscle fiber you wouldexpect the following to happen?

a) Generation of an action potential

b) Changes in DHPR status along thet-tubule

c) Increased SERCA activity

d) Hypertrophy of the muscle fiber

e) Decreased calcium levels outside thecell