What role do vitamins have in the pyruvate dehydrogenase reaction? There are FOUR correct answers.
A.Riboflavin is an electron carrier that functions in a redox reaction involving dihydrolipoamide.
B. Most children in developed countries have defective PDH protein complexes and suffer from malnourishment because they eat too much Captain Crunch cereal and not enough broccoli, asparagus, and brown rice.
C. Vitamin B5 functions as an acetate carrier using a high energy thioester bond formed in the E2 catalytic site.
D. One of the reasons why people get beriberi when their diets are lacking in vitamin B1 is that the PDH reaction becomes overstimulated and high levels of acetyl-CoA are toxic.
E. Thiamin pyrophosphate transfers a pair of electrons from E2 to E3, which in turn, oxidizes NAD+ to generate NADH + H+.
F. Vitamin B3 is a critical component of not only the PDH complex, but also the alpha-ketoglutarate dehydrogenase complex, an enzyme in the citrate cycle.
G.Vitamins provide functional chemical groups in all three subunits of the PDH protein complex.
What role do vitamins have in the pyruvate dehydrogenase reaction? There are FOUR correct answers.
A.Riboflavin is an electron carrier that functions in a redox reaction involving dihydrolipoamide.
B. Most children in developed countries have defective PDH protein complexes and suffer from malnourishment because they eat too much Captain Crunch cereal and not enough broccoli, asparagus, and brown rice.
C. Vitamin B5 functions as an acetate carrier using a high energy thioester bond formed in the E2 catalytic site.
D. One of the reasons why people get beriberi when their diets are lacking in vitamin B1 is that the PDH reaction becomes overstimulated and high levels of acetyl-CoA are toxic.
E. Thiamin pyrophosphate transfers a pair of electrons from E2 to E3, which in turn, oxidizes NAD+ to generate NADH + H+.
F. Vitamin B3 is a critical component of not only the PDH complex, but also the alpha-ketoglutarate dehydrogenase complex, an enzyme in the citrate cycle.
G.Vitamins provide functional chemical groups in all three subunits of the PDH protein complex.
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