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Queen Victoria and her role inspreadinghemophilia.

What is hemophilia

How is it passed (its method ofinheritance)

What is a carrier?

What is a karyotype?

Why is it useful to geneticists?

What diseases can be determined by usingit?

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Keith Leannon
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3 Apr 2019

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Related questions

Genetic

Genetic Variations

Research during the 1930s led to the discovery of an importantregion in human chromosomes known as the telomere. The enzymetelomerase enables the replacement of the telomere region in achromosome. Assure Jane Marlow that gene testing or DNA testing hasbecome a widely used tool to identify many disorders and can be avaluable tool for diagnosing conditions early on so thatappropriate steps can be taken to prevent further risks ofdeveloping diseases. Addresss the following:

  • What is the function of telomeres with regard to celldivision?
  • If a patient has an abnormality in telomerase activity, howmight this contribute to cancer?

Duchenne muscular dystrophy (DMD) is an X-linked disease forwhich prenatal diagnostic testing can be performed.

  • Has prenatal genetic testing increased the detection rate ofthis disease, compared to prior diagnostic methods?
  • If so, how? If not, why?
  • In case the fetus is diagnosed with DMD and parents decide toterminate the pregnancy, are there chances that the next child willalso be a carrier of the disease?

Jane Hill's husband, Charlie Marlow, has hemophilia A when hemarries Hill, who does not have the disorder. Jane's parents alsodo not have hemophilia, but her brother Steve Hill does.

  • What is the probability that the Marlows' son will have thedisorder?
  • What is the probability that their daughter will havehemophilia?
  • Are there chances that their daughter will be a carrier of thisdisorder?

1. If you had a fruitfly with phenotype A, what test would you make to determine if it was Aa or AA? Explain the different outcomes expected if the fly in question is AA or Aa.

2.The sex of birds, some insects, and other organisms is determined by a ZW chromosomal arrangement in which the males have like sex chromosomes (ZZ) and females are ZW (similar to XY in humans). Assume that a recessive lethal allele on the Z chromosome causes death of an embryo in birds. What sex ratio would result in the offspring if a cross were made between a male heterozygous for the lethal allele and a normal female?

3.A recessive gene for red-green color blindness is located on the X chromosome in humans. Assume that a woman with normal vision (her father is color-blind) marries a color-blind male. What is the likelihood that this couple's first son will be color-blind?

4. One form of hemophilia is caused by a sex-linked recessive gene. Assume that a man with hemophilia marries a phenotypically normal woman whose father had hemophilia. What is the probability that they will have a daughter with hemophilia? (Note: In this problem, you must include the probability of having a daughter in your computation of the final probability.)

5. One form of hemophilia is caused by a sex-linked recessive gene. Assume that a man with hemophilia marries a phenotypically normal woman whose father had hemophilia. What is the probability that their first son will have hemophilia?

2. In horses, the roan coat color pattern is caused by a completely dominant allele (RnRn) at the Kit locus, such that heterozygotes (RnRnRn+) are roan. The Kit locus is linked to the Extension locus, which determines chestnut coat color. If a horse has two copies of the recessive e allele, then the horse will be chestnut (red). The E allele is completely dominant to e and animals with one copy of the E allele will have a base color of bay (brown) or black. The Kit and Extension loci recombine at a rate of 7%.

A heterozygous roan, homozygous bay/black stallion (RnRnRn+ EE) is mated to a mare with genotype RnRnRn+ Ee (roan, bay/black). The mare’s two haplotypes are RnRn E and Rn+ e. What will be the expected genotype frequency of the progeny?

3. Hemophilia locus: Corneal dystrophy locus:

Two alleles Two alleles

H = wild-type/normal D = wild-type/normal

h = hemophilia d = corneal dystrophy

H is completely dominant to h D is completely dominant to d

Both loci are sex-linked

The recombination frequency between these two loci is 0.10 (or 10%)

A male dog with both hemophilia and corneal dystrophy has a normal female pup without either disorder. This female pup is now two years old and is expecting her first litter.

A. If her pup is male, what is the probability that he will have both hemophilia and corneal dystrophy?

B. What is the probability that her male pups would not have hemophilia and would have corneal dystrophy?

C. If a male pup has corneal dystrophy, what is the probability that he will not have hemophilia?

Please show work. I want to learn how to do these problems.

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