BIO SCI 97 Lecture Notes - Lecture 6: Null Allele, Fibroblast Growth Factor Receptor 3, Dwarfism

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11 Sep 2017

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Meaning, only homozygous recessive (dd) will have the disease. Affected kid is born to unaffected parents. If children are carriers, at least one parent has to be a carrier. Mutant allele is dominant over wild-type allele. Meaning, only homozygous recessive (dd) are the only disease-free individuals since disease is dominant so dd and dd are affected. Dominant trait/disease is found in every generation. Unaffected parents never produces an affected child. Shows up late in age for those that have the disease. Mendelian inheritance of an autosomal dominant allele. Of the offspring of an affected person are affected. Affected dad"s pass disease to all their daughters and none of their sons. X-linked recessive pedigrees can be also autosomal recessive (just all the males have the disease can be by chance) No since there"s a child being born to unaffected parents. How to determine what mechanism of inheritance a pedigree is:

Related Questions

1. A person is described as a carrier for a particular genetic disease. What does this tell you about their genotype?

2. For any given gene, the principle of independent segregation predicts that each gamete produced as a result of meiosis will contain ____________________

3. A pair of alleles is said to be heterozygous when:

4. In a diploid species, cells can have up to ___ alleles of a particular gene.

5. In a cross between a homozygous dominant parent and a homozygous recessive parent, the number of phenotypic classes observed in the offspring is ______

6. For a person of genotype Xx, the genotype of their gametes may be ______________

7. In a "test cross", an individual of unknown genotype is crossed with a ___ individual to determine the unknown genotype.

8. An albino woman has a child with a phenotypically normal man with no family history of albinism (which is a rare recessive disorder). What percentage of their children are likely to be albino?

9. An individual with the dominant phenotype, but an unknown genotype, is test-crossed, and all of the offspring exhibit the dominant phenotype. The genotype of the unknown individual is ______________

10. If two heterozygous individuals for a recessive disease (carriers) have a child, what is the chance that their child will develop the disease?

11. In a monohybrid cross between two true-breeding parents that both exhibit the dominant phenotype, ___ percent of the offspring will exhibit the recessive phenotype.

12. In a particular type of tomato plant, red fruit is dominant over yellow fruit, and dwarf height is a recessive trait. If two heterozygous plants were crossed, what proportion of the offspring would show the dominant phenotype?

13. In a cross between a BbRr individual and a BBRR one, what do the following represent: BR, Br, bR, br?

14. In humans, the gene that determines whether an embryo develops as a male or a female is carried on _____________

amaranthhare726

1. An animal (called a Box) is diploid, and has 5 types of chromosomes (4 autosomes, 1 pair sex chromosomes). Box sex chromosomes are designated W and Z. Box males are heteromorphic (WZ), and Box females are homomorphic (WW).

Boxes are covered in a thick coat of hair. There is a disease in Box, called hairlessness, that has an inheritance pattern that is W-linked and recessive. The allele used to designate this disease is h. Haired Box are wild-type (allele = h+) and hairless Box are mutant (allele = h). In general (not thinking about Box and hairless) when we say that an inheritance pattern is recessive, we automatically know some things about the genotype of affected/diseased individuals.

A) Is the trait simple, or some other type?

B) Does the presence of one diseased allele cause disease, or are two needed?

C) What other name do we use to describe a heterozygous individual?

In the case of Box and the hairless phenotype, what are all the possible genotypes for a hairless female? What are all the possible genotypes for a hairless male? (You do not need to use complete sentences here)

A heterozygous female is mated with an affected male. Indicate what gametes these two individuals can produce. (You donât need to use complete sentences here)

D) Draw a Punnett square for all the possible offspring that these two Box can create. Place the female gametes across the top of the square, and the male gametes down the left side. Insert a picture of your drawing below.

E) What is the ratio of unaffected to affected female offspring for these parents? For male offspring?

F) Choose one female offspring and one male offspring from the F1 and draw a Punnett Square for a mating between those two individuals (F2). Place the female gametes across the top and the male gametes down the left side. Take a picture of the square and insert it below.

BIO SCI 97 Lecture Notes - Lecture 6: Null Allele, Fibroblast Growth Factor Receptor 3, Dwarfism

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