Question

2. In horses, the roan coat color pattern is caused by a completely dominant allele (Rn^Rn) at the Kit locus, such that heterozygotes (Rn^RnRn⁺) are roan. The Kit locus is linked to the Extension locus, which determines chestnut coat color. If a horse has two copies of the recessive e allele, then the horse will be chestnut (red). The E allele is completely dominant to e and animals with one copy of the E allele will have a base color of bay (brown) or black. The Kit and Extension loci recombine at a rate of 7%.

A heterozygous roan, homozygous bay/black stallion (Rn^RnRn⁺ EE) is mated to a mare with genotype Rn^RnRn⁺ Ee (roan, bay/black). The mare’s two haplotypes are Rn^Rn E and Rn⁺ e. What will be the expected genotype frequency of the progeny?

3. Hemophilia locus: Corneal dystrophy locus:

Two alleles Two alleles

H = wild-type/normal D = wild-type/normal

h = hemophilia d = corneal dystrophy

H is completely dominant to h D is completely dominant to d

Both loci are sex-linked

The recombination frequency between these two loci is 0.10 (or 10%)

A male dog with both hemophilia and corneal dystrophy has a normal female pup without either disorder. This female pup is now two years old and is expecting her first litter.

A. If her pup is male, what is the probability that he will have both hemophilia and corneal dystrophy?

B. What is the probability that her male pups would not have hemophilia and would have corneal dystrophy?

C. If a male pup has corneal dystrophy, what is the probability that he will not have hemophilia?

Please show work. I want to learn how to do these problems.