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11 Aug 2018

1) How does an NLS help proteins interact with Karyopherin proteins?

2) What is the function of a karyopherin? How do they aid protein transit thru a nuclear pore?

3) How does GTP-Ran control the directionality of import by importin proteins?

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Beverley Smith
Beverley SmithLv2
13 Aug 2018

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Related questions

Nuclear proteins having a molecular mass more than approximately 40 KDa must be actively imported through nuclear pore complexes. What is the name given to the amino acid sequence (located in the protein that needs to be transported) that allows the selective transport of proteins into the nucleus? Name the three important factors that are required for the import of proteins into the nucleus and briefly describe how they function.

1)A friend works in a biotechnology company and has discovered a drug that blocks the ability of ran the echange GDP for GTP. What is the most likely effect of this drug on nuclear transport?

a)nuclear transport receptors would be unable to bind cargo.

b)nuclear transport receptors would be unable to enter the nucleus

c)nuclear transport receptors would be unable to release their cargo in the nucleus

d)nuclear transport receptors would interact irreversibly with the nuclear pore fibrils

2)After isolating the rough endoplasmic reticulum the the rest of the cytoplasm, you purify the mRNAs attached to it. Which of the following proteins do you expect the mRNA from the rough endoplasmic reticulum to encode?

a) plasma membrane proteins

b)ER membrane proteins

c)Soluble secreted proteins

d)all of the above

3)For both actin and microtubule polymerization, nucleotide hydrolysis is important for?

a)stablilizing the filaments once they are formed

b)increasing the rate at which subunits are added to the filaments

c)promoting nucleation of filaments

d)decreasing the binding strenth between subunits on filaments

Question 22

What intrinsic enzymatic activity do G proteins have?

They are ATPases

They are glycosidases

They are GTP synthases

They are GTPases

Question 23

How are G proteins activated?

The GTP dissociates from the G protein and GDP associates with the G protein

The GDP dissociates from the G protein and GTP associates with the G protein

The G protein synthesizes GTP from GDP

The G protein synthesizes GTP from ATP

Question 24

How are G proteins inactivated?

Hydrolyze ATP

Bind GTP

Bind ATP

Hydrolyze GTP

Question 25

What is a GTPase activating protein (GAP)?

It hydrolyzes GTP

It promotes release of GDP and binding of GTP of a G protein

It speeds up the rate of GTPase activty of a G protein

Question 26

What is a guanine nucleotide exchange factor (GEF)?

It speeds up the rate of GTPase activty of a G protein

It hydrolyzes GTP

It promotes release of GDP and binding of GTP to a G protein

Question 27

Which of the following types of enzyme activate G proteins?

GAP

GEF

Question 28

Which of the following types of enzyme inactivate G-proteins?

GAP

GEF

Question 29

What is receptor internalization and recycling?

It is when the receptor is co-translationally imported into the ER before being degraded by the unfolded protein response

It is when the receptor is endocytosed and then the vesicle fuses with the endosome, releases ligand and the receptor is returned to the plasma membrane

It is when the receptor is digested with proteases into amino acids and those amino acids are used to synthesize a new receptor

It is when the receptor cycles in and out of the nucleus

Question 30

How do large proteins get into the nucleus?

Simple diffusion

Facilitated diffusion through the nuclear pore

Active transport through the nuclear pore

Question 31

How easy is it for the following reaction to occur?

ADP + Pi → ATP

This is very exergonic and highly favorable

This is very endergonic and highly unfavorable

This is slightly exergonic and somewhat favorable

Question 32

The hydrolysis of ATP is highly...

Exergonic

Endergonic

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