BIO206H5 Study Guide - Final Guide: Nuclear Export Signal, Endoplasmic Reticulum, Nuclear Localization Sequence
Document Summary
Protein targeting worksheet: there are several things required for successful protein sorting. First of all, signal sequences are required to determine the correct destination of the protein. These are specific amino acid sequences that are part of the protein that can be removed at the final destination. In addition to these sequences, the protein must be transported along the correct pathway (nuclear, secretory, or translocation) via signal sequence receptors. The receptors assist in directing the protein towards the correct organelle or compartment. There are three types of transport mechanisms requires for successful protein sorting: gated nuclear pores, protein translocators, and transport vesicles. These mechanism assist the protein in traveling towards its destination with high specificity. Energy is also required to move the protein throughout the cell: in order to perform their function properly, sorting signals should carry a slight positive or negative charge.
