Answer the following questions concerning the polypeptides whose amino acid sequences are shown below. Explain your reasoning for all.
A) Gly-Ile-Trp-Leu-Ile-Ile-Phe-Gly-Val-Val-Ala-Gly-Val-Ile-Gly-Trp-Ile-Leu-Leu-Leu
B) Gly-Pro-Asp-Gly-Pro-Met-Gly-Pro-Ser-Gly-Pro-Arg-Gly-Pro-Glu-Gly-Pro-Asp-Gly
C) Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Pro-Leu-Leu
D) Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Cys-Leu-Leu
1. Which would be most likely to form an a-helical structure?
2. Which could have at least one disulfide bond?
3. Suppose that the first amino acid residue in peptide (1) were altered from Gly to Pro. Would you expect this change to have an effect on the secondary structure of this peptide? Why or why not?
Answer the following questions concerning the polypeptides whose amino acid sequences are shown below. Explain your reasoning for all.
A) Gly-Ile-Trp-Leu-Ile-Ile-Phe-Gly-Val-Val-Ala-Gly-Val-Ile-Gly-Trp-Ile-Leu-Leu-Leu
B) Gly-Pro-Asp-Gly-Pro-Met-Gly-Pro-Ser-Gly-Pro-Arg-Gly-Pro-Glu-Gly-Pro-Asp-Gly
C) Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Pro-Leu-Leu
D) Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Cys-Leu-Leu
1. Which would be most likely to form an a-helical structure?
2. Which could have at least one disulfide bond?
3. Suppose that the first amino acid residue in peptide (1) were altered from Gly to Pro. Would you expect this change to have an effect on the secondary structure of this peptide? Why or why not?
