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23 Nov 2019

Disease: Phenyketonuria

Describe the relationship between the disease phenotype (i.e., symptoms) and the

different genotypes with the disease-causing allele. In your description use the terms:

homozygous, heterozygous, dominant/dominance, and recessive. *Note: this will look

different if your disease is sex-linked!

a. Next, write out these different genotypes using capital letters for dominant

alleles, and lower-case letters for recessive alleles.

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31 Oct 2019
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Related questions

GENETICS : You perform a dihybrid cross between two dogs that are each BbFf. Where not specified otherwise, assume black fur B is completely dominant to white fur b and furry F is completely dominant to hairless f

1. What genotypes at one locus will be epistatic to what genotypes at the other locus, if hair color and hair presence were the only measured phenotypes? (you may find it helpful to write out the genotypes and the phenotypes each would produce, and remember that epistasis is involved in this question).

What phenotypic ratios would you expect in the following scenarios (assume, unless otherwise noted, that the epistasis in part 1 still applies)?

2. Black B is completely dominant to albino b, furry F is completely dominant to hairless f

3. Black displays incomplete dominance to albino , and furry is codominant with hairless

4. Animals that are heterozygous at either locus are black and furry, overriding the other locus' geneotype

5. The black allele B displays epistasis when present at even one copy that masks the effects of the hairless f allele

6. It takes two black B alleles to mask the effects of the hairless f allele

7. Both the black alleles B and furry alleles F are lethal in their homozygous dominant states

8. Both the albino alleles b and hairless alleles f are lethal in their homozygous recessive states

9. Female dogs die when they have homozygous recessive or homozygous dominant states for either locus (dogs use XY inheritance for sex like we do). Note sex of doss in your phenotype ratios.

10. The black allele B although completely dominant, is the only 70% penetrant in heterozygotes and is 90% penetrant in homozygotes for the B allele

11. The hairless allele f is dominant in males and recessive in females

Based on the following data from a three point testcross:

1. Determine the gene order and phase for the genes E, F and G.2

2. Determine the distance between genes E, F and G.

3. Draw a linkage map with the correct gene order, allele combinations on each chromatid and distance between the three genes.

For this exercise, phenotypes with capital letters are dominant and phenotypes in lower case letters are recessive. For example, “phenotype A” means the dominant phenotype for the gene and “phenotype a” means the recessive phenotype for that gene.

Show all your calculations. Remember that the three genes can be in any order. Remember that the dominant alleles do not necessarily need to all be on the same chromosome in the triple heterozygote parent.

Phenotypes

N

Efg

250

eFG

231

EFg

32

efG

38

EFG

11

efg

9

EfG

53

eFg

48

Total

672

Question 1

What would be the dimensions of a Punnett square for the cross Hh x hh?

4 x 4

2 x 2

2 x 1

1 x 1

Question 2

In dogs, the gene for fur color has two alleles. The dominant allele (G) codes for grey and the recessive allele (g) codes for black fur. The female dog is heterozygous. The male dog is homozygous recessive. Figure out the phenotypes and genotypes possible in their puppies by using a Punnett Square. (provide answers on one line with commas between - xx, xx, xx, xx)

Genotypes: , ,

Phenotypes: ,

Question 3

The fundamental Mendelian process which involves the separation of alleles located at the same spot on the chromosome would be called ___.

segregation

independent assortment

continuous variation

discontinuous variation

Question 4

Using the information given on dominant and recessive traits, state the phenotype for each genotype. Purple flowers are dominant to white flowers in pea plants.

-A.B.C.

PP_____________

-A.B.C.

Pp____________
-A.B.C.

pp_______________
A.

purple flowers
B.

purple flowers
C.

white flowers

Question 5

In dogs, the gene for fur color has two alleles. The dominant allele (G) codes for grey and the recessive allele (g) codes for black fur. The female dog has black fur and the male dog is homozygous dominant. Make a Punnett square to determine the chance of getting each genotype and phenotype below.

-A.B.

Probability of GG:
-A.B.

Probability of Gg:
-A.B.

Probability of gg:
-A.B.

Probability of gray fur:
-A.B.

Probability of black fur:
A.

100
B.

0

Question 6

Using the information given on dominant and recessive traits, state the phenotype for each genotype. Round seeds are dominant to wrinkled seeds in pea plants.

-A.B.C.

RR______________
-A.B.C.

Rr _____________
-A.B.C.

rr ____________
A.

round seeds
B.

wrinkled seeds
C.

round seeds

Question 7

Using the information given on dominant and recessive traits, state the phenotype for each genotype. Hairy knuckles are dominant to non-hairy knuckles in humans.

-A.B.C.

HH_____________
-A.B.C.

Hh ___________
-A.B.C.

hh _________________
A.

non-hairy knuckles
B.

hairy knuckles
C.

hairy knuckles

Question 8

An allele is ___.

one of the bases in DNA

an alternate form of a gene

another term for epistasis

present only in males and is responsible for sex determination

Question 9

In a cross of a round hybrid pea with a true breeding round parent (Rr x RR), what genotypic proportions would be observed in the offspring?

Half heterozygous, half homozygous dominant

Half round, half wrinkled

All heterozygous

All round

Question 10

What would be the dimensions of a Punnett Square depicting a dihybrid cross?

1 x 4

2 x 4

4 x 4

2 x 2

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