BIO230H1 Chapter Notes - Chapter 9: Nuclear Pore, Protein Targeting, Nuclear Membrane

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4 Nov 2016
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BIO230H1 Full Course Notes
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BIO230H1 Full Course Notes
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Chapter 12 - intracellular compartments and protein sorting. All eukaryotic cells have the same basic set of membrane enclosed organelles. Peroxisome: small vesicular compartment contain enzyme in oxidative reactions. Proteins can move between compartments in different ways. Move between cytosol and nucleus through nuclear pore complex and nuclear envelope. The transport of molecules between the nucleus and the cytosol. Inner nuclear membrane: protein acts as binding site for nuclear lamina. Each npc is composed of 30 different nucleoporins. Similarity suggests that they may derive from an early mebranebendin protein help membrane bends. Transmembrane ring protein, spans nuclear envelope, anchor npc t the envelope. Nuclear localization signals direct nuclear protein s to the nucleus. Nuclear import receptors bind to both nuclear localization signals and npc proteins. To initiate import, signal must be recognized by nuclear import receptors (importins) Adaptors structurally related to nuclear import receptors and recognize nuclear localization. Bind to the nuclear localization signal and the phenylalanine-glycine (fg) repeats.

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