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1. Two persons with the sickle cell trait marry and want to have children, but concerned about them having sickle cell anemia. What is the probability of sickle cell anemia in their children? What proportion of their children would you expect to be carriers?

2. If a person with the sickle cell trait marries a person with a normal hemoglobin, what is the probability they will have a child with sickle cell anemia? What proportion of their children would you expect to be carriers?

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26 Aug 2019
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Related questions

1) In one breed of house cats, orange and black fur isinherited. Two cats breed with the following cross: orange fur Xblack fur, and produce F1 with orange fur only. In and F1 x F1cross (to make the F2 generation), the progeny are 1/4 with blackfur and 3/4 with orange fur.

  1. Provide a key, which shows allelic designations of the furcolor and indicate which color is dominant and which isrecessive.
  1. Show the genotypes for the parents, F1, and F2 house cats fromthis problem.

2) Sickle-cell anemia is a recessive human disease that can bepassed down through generations. Maria and Sam Johnson are bothheterozygous for the sickle-cell gene.

  1. Maria is expecting! Yay! If Maria and her husband end up having4 children in total, what is the probability that at least two ofher children will have Sickle-cell anemia?
  1. If the couple has three children, what is the probability thatnone of the children are born with sickle-cell anemia?
  1. Turns out that Maria is having fraternal (non-identical) twins!What is the probability that both of the twins are boys and both ofthe twins have sickle-cell anemia?
  2. If she is having identical twins, what is theprobability that both twins have sickle-cell anemia?

Questions 4-6. Sickle cell disease:
Sickle cell disease (sickle cell anemia) is a relatively common disorder in individuals of

African descent and affects approximately 1 in 500 African-Americans. Due to a mutation in an autosomal gene for hemoglobin, the homozygous recessive genotype leads to red blood cells that are relatively stiff and sticky, and deform into a sickle shape as they lose oxygen. This leads to problems in the spleen, and anemia.

There are hundreds of different hemoglobin alleles. Individuals heterozygous for the sickle cell allele and one non-sickle cell allele usually do not experience major complications or even noticeable symptoms. A genetic test is available to diagnose carriers.

James does not have sickle cell disease, neither does his mother or father, but his sister does. His wife Natasha does not have sickle cell disease, and neither of her parents does either. Natasha also has a sister who has sickle cell anemia and two brothers without the disease.

5.) If James and Natasha have a child, what is the probability that the child would be a homozygote for the recessive allele and have sickle cell disease? You may draw the Punnet square but please solve the problem using probability calculations, then explain your reasoning in 2-5 complete sentences.

Sickle cell anemia and albinism are both recessive traits inhumans. Imagine that a couple, already pregnant with twins, hasjust learned that they are both heterozygous for both of thesetraits. As the couple's genetic counselor, the couple asks you thefollowing questions about how their carrier status will affecttheir offspring.

1.

If the couple has fraternal twins, what is the probability thatboth children will be unaffected by both conditions?

2.

If the couple has fraternal twins, what is the probability thatboth of the couple's children will have both sickle cell anemia andalbinism?

3.What is the probability that one of the fraternal twins is acarrier of either, but not both, of the conditions?
(Hint: You will need to use both the product law and the sum law toanswer this question.)

4.

If the couple has fraternal twins, what is the probability ofhaving two phenotypically normal children, one being a carrier ofonly the sickle cell anemia recessive allele, and the other being acarrier of only the recessive allele for albinism?
(Hint: You will need to use both the product law and the sum law toanswer this question.)

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