Question

MCB354FA15_PS04
Angiotensin converting enzyme (ACE) catalyzes the formation ofangiotensin II, a potent constrictor of blood vessels. ACEinhibitors are widely used to treat hypertension by reducingvasoconstriction. One such ACE inhibitor is enalapril, amulti-billion dollar per year drug for the treatment of high bloodpressure.
ACE has a KM of 12 mM for its substrate, which is present in plasmaat a concentration of 75 mM. When enalapril is present at 2.4 nM,the activity of ACE in plasma is 10% of its uninhibited activity.What is the value of Ki for enalapril?

Please explain how to to obtain the answer step bystep.