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13 Nov 2019

Which one of the following statements does NOT accurately describe the antigen-binding regions of antibody molecules?

A) The antigen-binding sites are formed by juxtaposition of variable regions of one heavy chain and one light chain.

B) The greatest amino acid variability among different antibody molecules is present in the complementarity-determining regions.

C) The variable regions of both light and heavy chains are composed of one immunoglobulin (Ig) domain.

D) The variable regions of heavy and light chains are at the C termini of the polypeptide chains.

E) There are six hypervariable loops in each antigen-binding site of an antibody molecule.

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Hubert KochLv2
23 Aug 2019
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Related questions

Select the true statements regarding antibody (specifically, immunoglobulin G) structure. Both the Fab and Fc fragments contain constant domains. Both the Fab and Fc fragments have variable domains. The antigen-binding site is formed as a combination of variable domains from one heavy and one light chain. The antigen-binding site is located in the Fc fragment. The heavy and light chains are linked by noncovalent and disulfide bonds.

Question 1

The antigen specificity of a BCR...

A. depends on the isotype of that BCR.
B. is the same as the antigen specificity of the secreted form of antibody produced by that cell.
C. is different for each of the BCRs on a cell.
D. is different for each of the Fab regions of the BCR.

Question 2

All BCRs on the surface of a B cell in a lymph node...

A. will have the same type of light chain (kappa/lambda).
B. will have the same type of light chain with the same exact amino acid sequence.
C. will each have a different type of light chain.
D. will have a lambda light chain on one Fab and a kappa light chain on the other Fab.

Question 3

The isotype of an antibody is...

A. determined by the light chain.
B. another word for an immunoglobulin Fab region.
C. determined by the heavy chain constant region.
D. determined by the Fc portion.
E. None of the above are correct

Question 4

Characteristics of lgG are...

A. a molecular weight of 900,000 and 10 antigen binding sites in the secreted form.
B. 165,000 molecular weight in the monomeric form but it is usually secreted as dimer.
C. the presence of more heavy chain constant regions than most antibodies but the lowest concentration in blood.
D. 150,000 molecular weight and the highest concentrations of all antibodies in blood.
E. None of the above describe IgG.

Question 5

Characteristics of lgM are...

A. 900,000 molecular weight and the secreted form has 10 antigen binding sites.
B. 165,000 molecular weight in the monomeric form but it is usually secreted as dimer.
C .the presence of more heavy chain constant regions than most antibodies but the lowest concentration in blood.
D. 150,000 molecular weight and the highest concentrations of all antibodies in blood.
E. None of the above describe IgM.

True / False Questions

01. _____ Antibody is composed of 2identical long heavy chains and 2 identical shorter lightchains.

02. _____ Variable (V) and constant(C) regions are part of both heavy and light chains.

03. _____ Variable regions for heavyand light chains from the same antibody molecule are alwaysidentical.

04. _____ Variable region of lightchains are encoded by the DNA sequences that contain rearranged V,D, and J segments.

05. _____ Fc part of the antibody isnot important, F(ab’)2 fragment has the same binding andeffector capacity.

06. _____ Fab fragments are generatedby alternative splicing.

07. _____ J chain is used as asurrogate light chain during pre-B cell receptor testing forsuccessful V(D)J rearrangement.

08. _____ Binding of the antigen byantibody is stabilized by disulfide bonds.

09. _____ RAG1/2 are always expressedin B cells at high level, because B cells need RAG1/2 to constantlyrearrange their V regions.

10. _____ “N” (non template)nucleotides are added by TdT.

11. _____ The 12/23 rule is appliedduring class switching.

12. _____ For B cells, V(D)Jrecombination occurs only in the bone marrow.

13. _____ The process of somatichypermutation helps to improve specificity of the antibody.

14. _____ In late pro-B cells, Vsegment is rearranged with DJ segments.

15. _____ Failure to eliminateself-reactive B cells may lead to serious autoimmune diseases.

16. _____ Mature, naïve B cellsexpress IgD and any of the other classes of antibody (IgM, IgG,IgA, or IgE) on their surfaces.

17. _____ B1 cells are present in theperitoneal cavity, pleural spaces and brain.

18. _____ AID (activation inducedcytidine deaminase) is expressed only in B cells and it canintroduce breaks in double stranded DNA.

19. _____ Different classes (isotypes)of antibodies have different effector functions, which aretriggered by special receptors expressed by a variety of cells.

20. _____ Plasma cells are terminallydifferentiated cells that produce large quantities ofantibodies.

21. _____ Repeated exposure to thesame antigen eventually leads to immunological exhaustion and lackof immunity, because there is no room for new plasma cells in thebone marrow.

22. _____ Germinal centers arespecialized sites within the bone marrow where Ig genes ofactivated B cells undergo affinity maturation.

23. _____ B cells can present antigensto T helper cells.

24. _____ Co-stimulatory molecules arerequired for efficient generation of memory B cells.

25. _____ Lymphocytes migrate to thelymphoid tissues in response to chemokines.

26. _____ Class switching duringgerminal center reaction is a random process.

27. _____ T cell independent responsescan generate strong and long lasting B cell memory.

28. _____ Fc receptors that arepresent on many different cell types are crucial for removal of thepathogens.

29. _____ The ideal vaccine should bedesigned to mimic the natural course of infection without causingsymptoms of the disease.

30. _____ The protective immunity canbe generated against any pathogen because there is virtuallyunlimited number of possible V regions, thus any antigen can berecognize by an antibody.

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