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10 Jan 2018

What is entatcin, how does it bind to integrins, how is it inhibited, and what are the effects of inhibitng it?

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Sixta Kovacek
Sixta KovacekLv2
11 Jan 2018
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Related questions

How do Cells Attach to the ECM?

Integrins: Apoptosis: What are triggers? What does this cause in cell? What is importance of location of PS (phosphatidyl serine) in cell membrane? Caspases (role and examples of targets in cell) Apoptosome (look at role of cytochrome c)

Choose only one correct answer

QUESTION 1

Transautophosphorylation occurs in which two of the followingsignaling pathways?

a.GPCR and RTK pathways

b.RTK and Integrin/FAK pathways

c.S/TKR and PKA pathways

d.GPCR and Ras pathways

e.MAPK and cAMP pathways

QUESTION 2

Which of the following receptors are activated by GTP?

a.G protein coupled receptors only

b.tyrosine kinase receptors only

c.both G protein coupled receptors and tyrosine kinasereceptors

d.neither G protein coupled receptors nor tyrosine kinasereceptors

QUESTION 3

Why can both GPCR and RTK pathways activate calmodulin?

a.Because both activate PLC

b.Because both activate PI3K

c.Because both trigger an action potential

d.Because both activate Ras

e.Because both activate PKA

QUESTION 4

Ion channel receptors __________ enzymes. They __________ bindsignaling ligands.

a.are, do

b.are not, do

c.are, do not

d.are not, do not

QUESTION 5

PIP2 is cleaved by ___________ to produce _____________.

a.phosphodiesterase, DAG and IP3

b. phospholipase C, DAG and IP3

c. phosphodiesterase, DAG and calcium

d. phospholipase C, DAG and calcium

QUESTION 6

Why are integrins considered to be signaling proteins?

a.Because they bind ECM

b.Because they bind heterotrimeric G proteins

c.Because they bind FAK

d.Because they bind MAPK

e.Because they bind Sos

QUESTION 7

Why isn’t tubulin considered a G protein?

a.Because it doesn’t propagate a signal in a signalingpathway

b.Because it doesn’t bind to GPCR

c.Because it doesn’t bind to a GEF or a GAP

d.Because it doesn’t undergo transautophosphorylation

e.Because it doesn’t bind GTP

1. Inflammation is generally a protective response, which would normally be beneficial. Is it an exclusively beneficial response? Explain 2 pts

2. You are a physician and your patient has had a heart attack resulting in decreased blood flow to the heart tissue. Once blood flow is reestablished, what might be a major concern? 2pts

3. One of the first steps in inflammation is the development of increased adhesiveness of neutrophils to the endothelium cells of venules. How does this occur? Give details 3 pts

4. What approach might stop the P- and E-selectin-mediated step in inflammation, thus blocking the process? 2pts

5. What sequence of events is triggered by the initial adhesion of neutrophils? 2pts

6. For no known reason, a person is found to make autoimmune antibodies against the ?2 subunit of leukocyte integrins. What symptoms, if any, is s/he likely to exhibit? (2pts each)

How might leukocyte adhesion deficiency be treated?

How might antibodies against the ?2 subunit of integrins prove useful medically?

7. Cancer cells from a person suffering from malignant melanoma are analyzed and found to have an elevated ability to bind to laminin; they also secrete much higher than normal levels of a certain proteolytic enzyme activity. How would these differences from normal, control cells promote metastasis of these cancer cells? Explain 4 pts

8. Why would cells that express less E-cadherin be more likely to become malignant and give rise to epithelial cell tumors? Explain 3 pts

9. What would happen if you were able to inject the gene for ?5?1 integrin (a fibronectin receptor) into some tumor cells in such a way that it was expressed extremely efficiently? Explain 3pts

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