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3 Mar 2018
1. The capsaicin response of TRPV1 is transient, i.e., the current is desensitized after initial activation when the external solution contains calcium ions. In addition, the current cannot be reactivated subsequently for a prolonged duration. Explain possible mechanisms that may cause the phenomena. 2. The topical application of capsaicin has an analgesic effect, meaning that it can render sensory neurons not only irresponsive to subsequent application of capsaicin but also irresponsive to other types of stimuli such as mechanical stimulus. Explain how this might happen. 3. Piezo channels inactivate and can lose inactivation in groups. How do you think the channels might communicate the loss of inactivation? 4. Piezo channels are large. What do you think might be the advantage to being big?
1. The capsaicin response of TRPV1 is transient, i.e., the current is desensitized after initial activation when the external solution contains calcium ions. In addition, the current cannot be reactivated subsequently for a prolonged duration. Explain possible mechanisms that may cause the phenomena.
2. The topical application of capsaicin has an analgesic effect, meaning that it can render sensory neurons not only irresponsive to subsequent application of capsaicin but also irresponsive to other types of stimuli such as mechanical stimulus. Explain how this might happen.
3. Piezo channels inactivate and can lose inactivation in groups. How do you think the channels might communicate the loss of inactivation?
4. Piezo channels are large. What do you think might be the advantage to being big?
Nestor RutherfordLv2
3 Mar 2018
