t-dependant cells vs t-independant cells? what are three differences ?
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With regards to cytotoxic T-cells, how are the activation requirements similar/different between mature naïve T-cells and CTLâs? Also, what differences in adhesion molecules and âeffectorâ molecules may be present between the 2 groups?
Understand that cells with different, specialized function would have differences in the number and variety of cellular organelles (and be able to give examples). Understand how cells carrying the same genes can nevertheless specialize in function (e.g. liver vs. muscle).
How does a mature, naïve T-cell become activated--what are the structures involved with this event (eg. lipid rafts, p56Lck, immunological synapses, adhesion molecules, co stimulatory molecules, etc.). Are other cells involved and how do they contribute? How are APC involved; are there differences between APC and their ability to activate T-cells?