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8 Jan 2018

How does the process of transduction in the rod photoreceptor amplify the signal contained in photons of light?

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9 Jan 2018
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Related questions

How and why amplication occurs when there are multiple steps in signal transduction pathway?

(how and why mult-step of the pathway can amplify the signal?)

The rod photoreceptors in the eye are extremely sensitive to light. Rod cells sense light through a signal transduction cascade involving light-activation of a G-protein coupled receptor that activates a G-protein, which activates cyclic GMP phosphodiesterase. Describe how you would expect the addition of the following drugs to affect the light-sensing ability of the rod cells. Explain your answers.

The outer segments of rod photoreceptor cells can be broken off, isolated, and used to study the effects of small molecules on visual transduction because the broken end of each segment remains unsealed. How would you expect the signaling pathway to be affected following the addition of a non hydrolyzable analog of GTP?

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