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7 Jan 2018

Class: Microbiology

Discuss the major histocompatibility complex with regard to its:

a. location

b. composition,

c. relationship to specific cell markers,

d. role in regulation of immune reactions

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Nelly Stracke
Nelly StrackeLv2
9 Jan 2018
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Related questions

Which statement about Major Histocompatibility Antigens is not true?

Select one:

a. they are found on every cell in the human body

b. there are class I and class II antigens

c. class II antigens are only found on antigen-presenting cells like macrophages

d. they are recognized by T cell receptors along with foreign epitopes

e. all of the above are true

Vl

How did inoculation with cowpox generate immunological memory and provide protection against smallpox? Did cross-reactivity play a role?

How did Pasteur’s work with attenuated (weakened) bacteria further our understanding of the role vaccination can play?

What are the three characteristics that define an adaptive immune response? Briefly define each of the characteristics.

Define primary versus secondary immune response.

What’s the difference between totipotent, pluripotent, multipotent and oligopotent when evaluating cell differentiation capacity?

What is hematopoiesis?

What cell types are derived from myeloid versus lymphoid progenitor cells? Describe the function of each WBC type.

What is clonal selection?

What role do antibodies play with regard to antigen recognition and immune defense that is different from what Tcrs provide?

As described in class generally understand the outcome of B cell, Th cell, and Tc cell activation. Understand that these cells can differentiate into effector (plasma cells, cytokine producing Th cells and CTLs) or memory cells.

Understand how granzymes and perforins play a role in apoptosis.

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With regard to Tc and Th cells, what kinds of peptide antigens (think about exogenously versus endogenously derived antigens) are recognized?

Be able to show cooperation between Tc, Th and B cell responses (refer to class notes).

What is the overall role of MHC Class I and II?

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Understand and be able to provide examples highlighting the cooperation between innate and adaptive immunity. Note: ADCC and dendritic cell and macrophage interactions with Th cells illustrate examples of innate/adaptive cooperation.

What are the primary lymphoid organs? What role do they play?

What role does the lymphatic circulatory system play in immune defense?

What’s the difference between plasma, ISF, and lymph?

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What is Leukocyte Adhesion Deficiency?

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What role does histamine play in the inflammatory response?

Describe the location and role of each of the following in the immune response.

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