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Which of the following may lead to cancer?

A mutation in the gene

A fault in the DNA repair procedure

Loss of control over the cell cycle

All of the choices

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Related questions

Suppose a person developed a mutation in a somatic cell which diminishes the performance of the body’s natural cell cycle control proteins. This mutation resulted in cancer, but was effectively treated with a cocktail of cancer-fighting techniques. Is it possible for this person’s future children to inherit this cancer-causing mutation? Be specific when you explain why or why not.

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Exposure to UV light results in thymine dimers between adjacentthymines in a single DNA strand. Describe how repair of this damagemight lead to a mutation.

7. DNA damage and repair

A: Can you identify types of DNA damage, and how that damage could alter base-pairing and lead to mutation?

B: What types of errors/damage are corrected by mismatch repair, base excision repair and nucleotide excision repair?

C: What is the function of a DNA glycosylase? DNA photolyase?

D: What are the most deleterious types of DNA damage? Can you think of examples of how these types of damage are exploited in therapeutics?

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