answers

watching

views

29 Dec 2018

Using the South University Online Library and the Internet, search and describe a genetic disorder that results from aberrant gene splicing. How does alternative splicing affect the disorder? Where in the gene does the aberrant splicing occur?

answers

watching

348

views

For unlimited access to Homework Help, a Homework+ subscription is required.

You have 0 free answers left.
Get unlimited access to 3.8 million step-by-step answers.

Get unlimited access

Already have an account? Log in

OC4149121Lv10

9 Jan 2022

Unlock all answers

Get 1 free homework help answer.

Already have an account? Log in

You have 0 free answers left.
Get unlimited access to 3.8 million step-by-step answers.

Get unlimited access

Already have an account? Log in

Collen VonLv2

31 Dec 2018

Already have an account? Log in

Related questions

QUESTION 5

The RNA component and not the proteins, of the RNA splicing machinery is responsible for splicing mRNA.

True

False

10 points

QUESTION 6

Which of the following is FALSE regarding Alternative Splicing? (Choose ALL that apply)

	A.	Alternative splicing occurs at extremely high levels in nervous tissue.
	B.	Alternative splicing alternates involves the inclusion of different exons within a given gene.
	C.	Alternative splicing involves the inclusion of different introns within a given gene.
	D.	Alternative splicing allow for multiple mRNA transcripts to be expressed from one gene

10 points

QUESTION 7

Which of the following is FALSE regarding Dissociator? (Choose the one correct answer.)

	A.	Movement of Dissociator only occurs during early development.
	B.	It is a transposable genetic element.
	C.	It 's presence within a color gene disrupts pigment production.
	D.	It's movement is controlled by a second element called 'Activator'.

10 points

QUESTION 8

An antigen can be a protein, nucleic acid, or a polysaccharide.

True

False

10 points

QUESTION 9

Which of the following statements is TRUE regarding the cell cycle? Choose ALL that APPLY.

	A.	CDKs are downregulated by cyclins.
	B.	Mature, differentiated cells exit the cell cycle into a resting phase called G0.
	C.	DNA damage that occurs after the Restriction Point will not arrest the cell cycle since the cell has passed the 'point of no return'.
	D.	CDKs are activated by CKIs

10 points

QUESTION 10

Homeotic genes display spacial colinearity.

True

False

A. To make an mRNA transcript from a gene, the RNA polymerase needs to 'know' where to start and to stop. What are the signals and proteins involved in initiating and terminating RNA polymerase activity in E. coli?

B. Alternative splicing is a key feature of the eukaryotic transcription-translation process.

i) In eukaryotes, alternative splicing of pre-mRNAs can result in the production of many structurally distinct proteins from information encoded in a single gene. Explain.

ii) Do lower eukaryotes (such as yeast, Saccharomyces cerevisiae) have the same opportunity to use alternative splicing to generate a vast array of proteins from a single gene? Explain.

iii) What other splicing events can lead to additional diversity in the repertoire of proteins that could be encoded by a single gene? Hint: think of the N and C terminal ends. What about a post-translational mechanism. Name one.

Question 2. Splicing is complicated. There isconstitutive splicing, and then there is regulated alternativesplicing, and these molecular events can occur in the same ordifferent tissues.

a. What is constitutive splicing?

b. What is alternative splicing?

c. Draw a gene with three exons and twointrons. In this example assume exons 1,2,3 are expressed in onetissue and exons 1,3 are expressed in another. Draw the alternativesplicing, and the resulting RNA from this gene.

d. Draw a model illustrating how sterichindrance can promote alternative splicing with in a gene.

e. An individual is heterozygous, one copy ofthe gene has a mutation in exon 1 and the other copy of the gen ehas a mutation exon 3. Draw their genes, with mutations. What RNAmolecules can be expressed from these alleles? Will thisheterozygote have a mutant or a wild - type phenotype? Explain.Assume the 1/3 variant and the 1/2/3 variant are required indifferent tissues

Question 3 . You haveidentified a 4 exon gene expressed in the nervous system of adiploid animal. Different splice variants are expressed in thenervous tissue at the same time. T he organism under study has agene, unc - 250 , that controls movement and has three differentrecessive mutant alleles: allele s a 1 , a2 , and a3 . All threemutations are nonsens e stop mutations. When a diploid organism ishomozygous for allele a 1 animals die. When homozygous for eitherallele a2 , or allele a3 , animals are very uncoordinated in theirmovement (unc). Alleles a2 and a3 fail to complement allele a1 ,that is to say a1 / a2 and a 1 / a3 heteroallelic animals are veryuncoordinated in their movement (unc). However, a2 / a3 animals arewild type, ie they complement. Using alternative splicingconstruct a logical model for these observations and show whereeach of the mutations would be located in the gene.

crimsonimpala955

Weekly leaderboard

Home

Homework Help 3,900,000

Biology 460,000

Using the South University Online Library and the Internet, search and describe a genetic disorder that results from aberrant gene splicing. How does alternative splicing affect the disorder? Where in the gene does the aberrant splicing occur?

Unlock all answers

Related textbook solutions

Molecular Cell Biology

Biology: Science for Life with Physiology

Concepts of Biology

Biology

Essentials of Biology

Related questions

Related Documents

BIO 4115 Study Guide - Final Guide: Electrophoretic Mobility Shift Assay, C-Terminus, Rna Recognition Motif

BIO 1140 Lecture Notes - Lecture 6: Rna Splicing, Guide Rna, Alternative Splicing

BIO230H1 Lecture Notes - Lecture 5: Cleavage And Polyadenylation Specificity Factor, Cytosol, Nuclear Membrane

Weekly leaderboard