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12 Aug 2018

Match the following DNA damage with the repair mechanism that would be responsible for repairing it: (type of repair mechanism )

a) A double-strand break induced by Spo11 in meiosis

b) An incorrectly inserted base during DNA replication

c) A minor lesion that alters the pairing potential of a base, for example 8-oxoguanine

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Tod ThielLv2

12 Aug 2018

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Please help with some epgenetics! I got partial credite for the answers I put but I'm not sure which ones I got wrong!

1) Match the repair pathway to the type of damage it most commonly repairs.

a. Non-homologous end joining

b. Nucleotide excision repair

c. Mismatch repair

d. homologous recombination

e. photolyse

Choices: double strand breaks, UV-induced photodamage, replication error, spontaneous depurination, 5-methyl cytosine

My answer: a. 5-methyl cytosine, b. UV-induced photodamage, c. replication error, d. double strand breaks, e. spontaneous depurination

2) Match the human diseas to the repair patheay that is deficient that disease. Answers may be used more than once.

a. Hereditary polypsis colorectal cancer

b. Xeroderma pigmentosum

c. Ataxia telangiectasia

d. Fanconi Anemia

Choices: mismatch repair, nucleotide excision repair, double strand break repair, base excision repair, photolyse

My answer: a. mismatch repair, b. nucleotide excision repair, c. mismatch repair, d. double strand break repair

3) ____ (a) is a histone chaperone that is recruited by the PCNA and binds to newly synthesized _____(b).

______ (c) is a histone chaperone that acts during the replication-independent assembly pathway, when _____ (d) is incorporated into chromatin.

______(e) is a thrid chaperone that is recruited to replication forks by the replicative helicase.

My answers: a. CAF1, b. H3 and H4, c. H3.3, d. nucleosomes, e. ASF

lemonchinchilla287

Match each statement with one of the choices (A-E)

A.) Uracil N-glycosidase B.) AP repair C.) SOS repair D.)Nucleotide excision repair E.) Proof-reading

21.) Deficits in this system account for the UV-sensitivity ofaptients with Xeroderma pigmentosum.

22.) When this "repairs" DNA damage that reuslts from aparticular deamination, it creates an AP site which must besubsequntly repaired by the AP repair system

23.) This inducible, post-replication" repair system is errorprone because it allows DNA polymerase to "bypass" or read-throughthe replication blocks that occur wherever DNA damage precludes thepossibility of normal base-pairing.

24.) This repairs the damage that results from spontaneousdepurination of DNA

25.) In wild type E.coli, most of the replication errors thatresult from tautomeric shifts are repaired by this

I think 21 is D, 22 is A, and 24 is B, but I'm not completelysure. Please help!!

scarlethare196

I need help.

what could be a mechanisms for the phage induction process exit from the genome?

It has been observed that bacteriophages, like the lambda phage, that have integrated into their host genome (prophage) are induced to cut themselves out of the genome when exposed to DNA damage. Prophage are able to remain in the genome by producing a single repressor protein that keeps the genes turned off that are normally used in replication and for the production of structural proteins during active phage amplification. From your knowledge of the induction of cellular repair, propose a mechanism for the phage induction process to exit from the genome.