A) Compare and contrast the activities of AMP-dependent protein kinase and cAMP dependent protein kinase. First of all, give the general functions of cAMP dependent protein kinase (PKA) and AMP activated protein kinase (AMPK).
i) Describe the reactions catalyzed by these enzymes, the overall functions of PKA and AMPK and the allosteric activators and inhibitors of these enzymes. Explain why do these allosteric regulators make sense?
ii)What are the hormones that lead to stimulation and inhibition of these enzymes and relate to the overall functions of these hormones on body.
iii)What are the biochemical targets and effects of these two enzymes in heart, skeletal muscle, liver, heart and adipose? Include detail including overall functions, metabolic pathways, etc. Details required
A) Compare and contrast the activities of AMP-dependent protein kinase and cAMP dependent protein kinase. First of all, give the general functions of cAMP dependent protein kinase (PKA) and AMP activated protein kinase (AMPK).
i) Describe the reactions catalyzed by these enzymes, the overall functions of PKA and AMPK and the allosteric activators and inhibitors of these enzymes. Explain why do these allosteric regulators make sense?
ii)What are the hormones that lead to stimulation and inhibition of these enzymes and relate to the overall functions of these hormones on body.
iii)What are the biochemical targets and effects of these two enzymes in heart, skeletal muscle, liver, heart and adipose? Include detail including overall functions, metabolic pathways, etc. Details required
