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Please breifly explain development of the following structures 1. Development of the face 2. Development of the tongue 3. Development of the palate 4. Development pf the parathyroid, thyroid, thymus glands

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Keith Leannon
Keith LeannonLv2
28 Sep 2019

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Short Answer part 1.

1. What is Notch1, including where it is expressed, and how does the interaction between Notch1 and its ligand mediate T cell development?

2. In what way the thymic conditions is advantageous for the purposes of negative selection?

3. The surrogate light chain operating during pre-B cell development is made up of VpreB:lambda5. Its expression with mu on the pre-B cell surface is an important checkpoint in B cell maturation. Name the T cell analog of VpreB:lambda5 and discuss how it is functionally similar.

4. Mature B cells undergo somatic hypermutation after activation, which, after affinity maturation, results in the production of antibody with a higher affinity for antigen than in the primary antibody response. Suggest some reasons why T cells have not evolved the same capacity.

5. As we age, our thymus shrinks, or atrophies, by a process called involution, yet T cell immunity is still functional in old age. How do T cell numbers in the periphery remain constant in the absence of continual replenishment from the thymus and how does this differ from the maintenance of the B cell repertoire?

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