Short Answer part 1.
1. What is Notch1, including where it is expressed, and how does the interaction between Notch1 and its ligand mediate T cell development?
2. In what way the thymic conditions is advantageous for the purposes of negative selection?
3. The surrogate light chain operating during pre-B cell development is made up of VpreB:lambda5. Its expression with mu on the pre-B cell surface is an important checkpoint in B cell maturation. Name the T cell analog of VpreB:lambda5 and discuss how it is functionally similar.
4. Mature B cells undergo somatic hypermutation after activation, which, after affinity maturation, results in the production of antibody with a higher affinity for antigen than in the primary antibody response. Suggest some reasons why T cells have not evolved the same capacity.
5. As we age, our thymus shrinks, or atrophies, by a process called involution, yet T cell immunity is still functional in old age. How do T cell numbers in the periphery remain constant in the absence of continual replenishment from the thymus and how does this differ from the maintenance of the B cell repertoire?
Short Answer part 1.
1. What is Notch1, including where it is expressed, and how does the interaction between Notch1 and its ligand mediate T cell development?
2. In what way the thymic conditions is advantageous for the purposes of negative selection?
3. The surrogate light chain operating during pre-B cell development is made up of VpreB:lambda5. Its expression with mu on the pre-B cell surface is an important checkpoint in B cell maturation. Name the T cell analog of VpreB:lambda5 and discuss how it is functionally similar.
4. Mature B cells undergo somatic hypermutation after activation, which, after affinity maturation, results in the production of antibody with a higher affinity for antigen than in the primary antibody response. Suggest some reasons why T cells have not evolved the same capacity.
5. As we age, our thymus shrinks, or atrophies, by a process called involution, yet T cell immunity is still functional in old age. How do T cell numbers in the periphery remain constant in the absence of continual replenishment from the thymus and how does this differ from the maintenance of the B cell repertoire?
