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Explain how you can prevent cancer by preventing cell growth (Using the cell cycle check points and G1/ S cyclin/ CDK) and trigger cell death

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Jamar Ferry
Jamar FerryLv2
17 Apr 2019

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Related questions

For your responses please justify your answer. No justificationfor answer will recieve "needs work" rating.

32. Which statements concerning the regulation of CDK/cyclincomplexes are correct?
A. At different points in the cell cycle, G1 and mitotic cyclinscan activate the same CDK subunit.
B. Phosphorylation of CDK proteins can both activate and inhibitcyclin/CDK activity.
C. If CAK has phosphorylated the CDK subunit, CDKs will remainactive in the absence of cyclin.
D. The CDK/G1 cyclin complexes that control S phase initiation arelikely to have signal sequences
that target them for nuclear import.
F. Cyclin/CDK complexes are frequently targets of cell cyclecheckpoint pathways.

33. Which of the following statements concerningubiquitin-mediated proteolysis are correct?
A. Ubiquitin modification serves as a molecular “tag” to signaldegradation by the proteosome.
B. Both G1 and mitotic cyclins are targets for ubiquitin-mediatedproteolysis.
C. Nuclear envelope breakdown during mitosis is accomplished byubiquitin-mediated
proteolysis of lamin intermediate filament proteins.
D. The separation of sister chromatids at the metaphase to anaphasetransition is controlled by
ubiquitin-mediated proteolysis of an anaphase inhibitor.
E. Conditional mutations that inactivate the gene encodingubiquitin in yeast would be expected
to exhibit a cdc phenotype.

When researchers inject purified mitotic cyclin/cdk proteincomplexes into cells that are in S phase of the cell cycle, thecell immediately begins mitosis (M phase), skipping over the G2phase. Explain why this happens and speculate on what theconsequences may be for the cell going into M phase early. In youranswer, describe the function of the mitotic cyclin/cdk complex(in detail).

The survival, __________________, and size of each cell in an animal are controlled by extracellular signal molecules secreted by neighboring and distant cells. Many of these signal molecules bind to a cell-surface __________________ and trigger various intracellular signaling pathways. One class of signal molecules, called __________________, stimulates cell division by releasing the molecular brakes that keep cells in the __________________ or __________________ phase of the cell cycle. Members of a second class of signal molecules are called __________________, because they stimulate cell growth and an increase in cell mass. The third class of signal molecules, called __________________, inhibits __________________ by regulating members of the __________________ family of proteins. In addition to such stimulatory factors, some signal proteins such as __________________ act negatively on other cells, inhibiting their survival, growth, or proliferation.

anaphase differentiation myostatin

annihilation G0 nourishment

apoptosis G1 nutrition

arrestase G2 phosphatases

Bcl2 growth factors proliferation

biosynthetic interphase receptor

cascades ligand S

caspase M survival factors

Cdk mitogens transcription

cyclin

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