For your responses please justify your answer. No justificationfor answer will recieve "needs work" rating.
32. Which statements concerning the regulation of CDK/cyclincomplexes are correct?
A. At different points in the cell cycle, G1 and mitotic cyclinscan activate the same CDK subunit.
B. Phosphorylation of CDK proteins can both activate and inhibitcyclin/CDK activity.
C. If CAK has phosphorylated the CDK subunit, CDKs will remainactive in the absence of cyclin.
D. The CDK/G1 cyclin complexes that control S phase initiation arelikely to have signal sequences
that target them for nuclear import.
F. Cyclin/CDK complexes are frequently targets of cell cyclecheckpoint pathways.
33. Which of the following statements concerningubiquitin-mediated proteolysis are correct?
A. Ubiquitin modification serves as a molecular âtagâ to signaldegradation by the proteosome.
B. Both G1 and mitotic cyclins are targets for ubiquitin-mediatedproteolysis.
C. Nuclear envelope breakdown during mitosis is accomplished byubiquitin-mediated
proteolysis of lamin intermediate filament proteins.
D. The separation of sister chromatids at the metaphase to anaphasetransition is controlled by
ubiquitin-mediated proteolysis of an anaphase inhibitor.
E. Conditional mutations that inactivate the gene encodingubiquitin in yeast would be expected
to exhibit a cdc phenotype.
For your responses please justify your answer. No justificationfor answer will recieve "needs work" rating.
32. Which statements concerning the regulation of CDK/cyclincomplexes are correct?
A. At different points in the cell cycle, G1 and mitotic cyclinscan activate the same CDK subunit.
B. Phosphorylation of CDK proteins can both activate and inhibitcyclin/CDK activity.
C. If CAK has phosphorylated the CDK subunit, CDKs will remainactive in the absence of cyclin.
D. The CDK/G1 cyclin complexes that control S phase initiation arelikely to have signal sequences
that target them for nuclear import.
F. Cyclin/CDK complexes are frequently targets of cell cyclecheckpoint pathways.
33. Which of the following statements concerningubiquitin-mediated proteolysis are correct?
A. Ubiquitin modification serves as a molecular âtagâ to signaldegradation by the proteosome.
B. Both G1 and mitotic cyclins are targets for ubiquitin-mediatedproteolysis.
C. Nuclear envelope breakdown during mitosis is accomplished byubiquitin-mediated
proteolysis of lamin intermediate filament proteins.
D. The separation of sister chromatids at the metaphase to anaphasetransition is controlled by
ubiquitin-mediated proteolysis of an anaphase inhibitor.
E. Conditional mutations that inactivate the gene encodingubiquitin in yeast would be expected
to exhibit a cdc phenotype.
