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Phenylketonuria is an inherited disease caused by a recessiveautosomal allele. If a woman and her husband are both carriers,what is the probability that their first child will be aphenotypically normal girl?

Please explain all your work in order to receive a lifesaverrating. Thank you very much! =)

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Lelia Lubowitz
Lelia LubowitzLv2
28 Sep 2019
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Related questions

Phenylketonuria is an inheriteddisease caused by a recessive autosomal allele. If a woman and herhusband are both carriers, what is the probability that their firstchild will be a phenotypically normal girl?

Answer: 3/8

Why is this the correct answer? Ithought it was wrong, but I had a similar problem on my test withthe same answer. Can someone explain? Thank you!

1) A sex-linked recessive allele of gene B is the subject of this problem. Assume that a man with the recessive allele marries a woman with a normal phenotype. The woman's father had the recessive allele too. What is the probability that the couple will have a daughter with the recessive phenotype?

2)Albinism is inherited as a simple recessive trait. If a woman and her husband are both heterozygous for albinism then what is the probability that their first five children will have these phenotypes? Child 1 - albino; child 2 - normal; child 3 - normal; child 4 - albino; child 5 - normal?

3)Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as an X-linked recessive gene in humans. A woman whose father suffered from G6PD marries a normal man. (a) What proportion of their sons is expected to be G6PD? (b) If the husband were G6PD deficient would you change your answer in part (a)?

Type 1 Gaucher disease is a rare disorder resulting from not having enough glucocerebrosidase, an important enzyme that breaks down a fatty chemical called glucocerebroside. It is caused by an autosomal recessive allele and the disease is most common in population groups in which consanguineous marriage is not unusual. A woman is married to her first cousin, and the couple is planning to have a child, but discovers that their shared grandmother’s brother suffered from type 1 Gaucher disease (assume others in the family don’t have Type 1 Gaucher disease).

1. Draw the relevant parts of the pedigree (starting from the couple’s shared great grandparents).

2. What is the probability that the couple’s first child will have Type 1 Gaucher disease, assuming that all people who marry into the family are homozygous for the normal allele?

3. If the couple’s first child turns out to have type 1 Gaucher disease but the second child does not have it, what is the probability that their second child is a carrier?

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