BIOS10115 Lecture Notes - Lecture 13: Neutrophil, Sebaceous Gland, Phagocytosis

• School: ND
• Department: Biological Sciences
• Course: BIOS10115
• Professor: Patricia Vaughan

Document Summary

The immune system: innate (non-specific) 1st line of depense, adaptive (specific) 2nd line of defense protects/re-exposure. Specific (adaptive) respond to particular agents: antibodies specific cells. Nonspecific (innate, born with) respond to all invaders first line of defense: physical barriers, chemical barriers, cellular defenses. Skin is the largest organ of the human body and an excellent physical barrier to microorganisms. Penetratino of the skin (tattoes, etc. ) can allow external microbes to invade the human body. Ma(cid:374)(cid:455) (cid:862)s(cid:455)(cid:373)pto(cid:373)s(cid:863) are a(cid:272)tuall(cid:455) ph(cid:455)si(cid:272)al (cid:271)arriers: mucus, coughing and sneezing, vomiting and diarrhea. Blood: ~60% plasma/serum (liquid, ~40% formed elements. Formed elements: red blood cells (erythrocytes) Embryonic stem cells pluripotent can become anything. Myeloid: basophils release histamine, mast cells release histamine, eosinophils increase in allergic reaction, neutrophils. Steps in phagocytosis: chemotaxis specific chemicals, cytokines. Moving toward the chemical/invaders: adherence and ingestion, digestion. Some microbes have evolved to specifically resist phagocytosis at any one of these steps. High # in blood count suggests infection.