PSL301H1 Lecture Notes - Lecture 38: Balloon, Peptic Ulcer, Helicobacter Pylori
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Psl301 lecture 38: control and disorders/diseases part ii. Could have blood loss if lining is severely damaged. Barry marshall drank a broth of cultured bacteria of helicobacter pylori to prove that it"s the bacteria that caused ulcers had non-acid vomiting. Excess acid (e. g. zollinger ellison (tumor), pseudo-zollinger ellison (g cell hyperplasia)) excessive secretion of gastrin. Stress ulcers (physiological stress), others organ trauma, head injury (cushing"s ulcer) Humans are the only known reservoir, can be carriers but not known. Urea combines with water and with enzyme urease forms bicarbonate and nh4. H. pylori secretes urease within the stomach, that urease converts urea into bicarbonate, neutralize the acidity in the stomach. Caga: cytotoxin associate gene a inject into epithelial cells, localize inner membrane, cause epithelial cells to change and a docking site for the bacteria. Hp-nap: h. pylori neutrophil activating protein recruit inflammatory cells.
