PSL301H1 Lecture Notes - Lecture 27: Perfusion, Hyperglycemia, Diuretic
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Note: filtration rate in a healthy individual is 100ml/min it will take 6 min for someone to filtrate 600 ml bottle of water. Na+ is the major positive solutes that sits in the ecf (while k+ is the major positive solutes that sits in the icf) Regulates blood volume, blood pressure, and organ perfusion. Deficit of na+: low bp, and low organ perfusion. Early humans: they live in low na+ environments because salt was scarce. Therefore, they had high k+, and less na+ in their body. As a consequence, their kidneys are exceptionally good at reabsorbing filtered na+ Human kidney is designed to retain sodium for a stable blood volume. In the present time, human eat too much salt relative to the type of diet we have evolved. Osmotic diuresis hyperglycemia (high levels of sugar) Diuretics (drugs that increase production of urine) Proximal tubule 70% reabsorption of na+ Na+ is rapidly reabsorbed in the proximal tubule (pct)
