PSL301H1 Lecture Notes - Lecture 26: Tubular Fluid, Efferent Arteriole, Afferent Arterioles
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Filter plasma water and solutes at the glomerulus. Despite what we eat and drink, solute concentration will remain in equilibrium between. In the tubule, water and solutes can be reabsorbed or not glomerulus and tubule. Tubular physiology: water: the plasma volume enters the renal system via afferent arteriole; volume = 100, only 20% of the volume are filtered in the bowman"s capsule, and to the tubule. Normal gfr: >100 ml/min or 150 l/day. Normal urine volume: 0. 5 - 2. 0 l/day (depends on how much you drink) Filtered sodium: >22,500 mmol of na+ per day, but only excrete 150 mmol per day (depends on what you eat) Sodium reabsorbs, water will follow sodium water reabsorbs. Epithelial cells are polarized (basal lamina and an apical side) Different transport proteins are present in liminal membrane (apical) and basolateral (blood) membrane. Na/k atpas is located on basolateral membrane. Na/k atpas maintains a low intracellular concentration of na+ (puts na out, k in. )
