BIO200H5 Lecture Notes - Lecture 5: Suicide Inhibition, Conformational Change, Naloxone
Document Summary
Pharmacodynamics: what the drug does to the body. Determines how the drug is classified (reversible vs. irreversible) Helps determine if drug is best for the specific disease. Whether it"s a suicide inhibitor or not. Pharmacokinetics: what the body does to the drug. Governs how drug is absorbed (into bloodstream), disturbed by body, metabolized, Drug + target (protein, dna, etc. also called receptor) effect. Blocks target from interacting with other cellular molecules. Effector mechanism : how drug alters cell communication. Proteins used as effectors to tell us how the protein works. = functional role; communicates effect of drug:target interaction to rest of cell. Drug binding to protein target = . Drug binding can cause effect directly or indirectly. Directly when the drug goes directly through and changes shape of the protein. Indirectly when the drug hits a enzyme and indirectly hitting a protein causing it to not work. Fast ( ex. /enzyme) or slow (ex. gene regulation) response.
