BIO200H5 Lecture Notes - Lecture 3: Postmarketing Surveillance, Covalent Bond, Drug Action
Document Summary
I. e. reversible inhibitor (binds for short period of time; temporary) I. e. suicide inhibitor (binds irreversibly to target; permanent effect) Suicide inhibitor - part that is attacked by a protein forming a covalent bond to the protein. Action of drug will affect the dosage - we must control over how the chemistry will interact with the biology. Knowledge of the interaction of it with other proteins. Ideally, you want a drug candidate that: we have a specific molecule in mind which we use for binding, we need 3 main pieces of information from the target. Is stable to metabolism and degradation (i. e. digestive system, enzymes) Build structure of potential drug molecules virtually from scratch: main sources of inspiration of rational designing - natural products - isolated from, many things occur which change a protein behaviour. Design de novo - imagination and knowledge of interaction. Tools used to rationally design drugs- x-ray crystallography.
