BIO200H5 Lecture Notes - Lecture 8: Cytochrome P450, Endocytosis, Protonation
Document Summary
Even if drug binds to only . Biological process controlled = takes place in many cell types. Receptor function = coupled to many . Same receptor, 2 very different functions in body. Adverse effects : people with asthma (causes constriction of airways and. Four mechanisms that can contribute to variation in drug response: Factors that can help predict variation in response: Change in # or function of receptors/targets. Changes in intracellular signal away from receptor. There are variations in response to drugs. Clearance of drug is affected by the amount we can tolerate. If body produces more endogenous liquid than tolerable - that affects the response. Changes in another pathway ultimately involved - effects out variation to drug response. Even if rationally designed for specific target: Drugs can still display binding to different classes of targets/receptors; . Drugs can bind to different receptors in same family/receptor type. Strategies to lower toxicity caused by binding to .
