NUTR 3210 Lecture Notes - Lecture 16: Low-Density Lipoprotein, Ldl Receptor, Very Low-Density Lipoprotein
14 Nov 2016
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Document Summary
As the lipoprotein gets smaller (lipids are removed), the proportion of protein in the particle increases. Chylomicron (tg rich: largest lipoprotein, high lipid/low protein composition, apob/c/e present, delivers dietary tg to tissues; becomes a chylomicron remnant. Very low density lipid (vldl) tg rich: second largest, high lipid/low protein, apob/c/e, delivers hepatic tg to tissues; becomes ldl. Low density lipid (ldl) ce rich: second smallest, compared to vldl is has a higher protein:lipid ratio, apob/c/e, delivers cholesterol to tissues (needed for membranes and steroid hormones), but also to blood vessels (not good) High-density lipid (hdl: smallest, high protein/low lipid, apoa family, collects cholesterol from vessels, returns it to liver (good, prevents progression of atherosclerosis) The fates of liver cholesterol: converted to bile acid/salts, secreted directly as cholesterol with bile into the duodenum, repacked into vldl particles and released into the blood stream. ** the balance of these processes will help to determine the levels of ldl cholesterol in the blood stream.
