ANAT 262 Lecture Notes - Lecture 22: Cholesteryl Ester, Differential Centrifugation, Ldl Receptor

• School: McGill University
• Department: Anatomy & Cell Biology
• Course: ANAT 262
• Professor: Ursula Stochaj

Document Summary

Storage forms in lipoprotein particles or lipid droplets. Enzymes that synthesize storage lipids are found in er membranes. Dgat2 can sometime move to lipid droplets" membrane. Last step: diacylclycerol (hydrophobic & hydrophilic parts) dgat add fatty acid coa (completely hydrophobic) triglyceride completely hydrophobic, insoluble in water/membranes. Cholesterol has oh, a little polar, in membranes. Cholesteryl oleate example of cholesterol ester, lose h lose hydrophilic character, completely nonpolar. Cholesterol ester: cholesterol + fatty acids, insoluble, unstable in membrane. Dgat1, dgat 2 in er membranes, synthesize triglycerides. Triglycerides & cholesterol esters mixed together in er membrane, surrounded by lipid bilayer. Cholesterol esters & triglycerides moved to lipid droplets (lipid monolayer) All cell types capable of forming lipid droplets into cytosol. Enterocytes & hepatocytes: can form lipoprotein particles into er lumen secretory pathway. Main mechanism to move cholesterol & fatty acids (as cholesterol esters & triglycerides) b/w cells. Formation of lipoprotein particle, in enterocytes & hepatocytes.