BIOL 1F25 Lecture Notes - Lecture 2: Insecticide, Odds Ratio, Geographic Information System
25 Feb 2016
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1st clues to environmental causes of parkinson"s disease: langston et al. , 1983. 4 patients: 1 female, 3 males, ages 26-42 years, all had history of heroin abuse (3 months 14 years, 2 obtained new heroin in watsonville, mid june, 2 obtained new heroin in san jose, july 1. Symptoms as severe as advanced parkinson"s disease (develops over many years) Mptp (a by-product of the chemical reaction to make mppp: student died; autopsy showed loss of nerve cells in substantia nigra in brain, synthesis: ziering et al. , j organic chem 1947 (article removed from university library!) Patients in california injected themselves with mppp or mptp and . Injection of mppp or mptp kills nerve cells in substantia nigra and causes symptoms of parkinson"s disease. If drug killed in substantia nigra that release dopamine, drugs that treat. All 4 patients received l-dopa / carbidopa. All 4 patients showed some relief of symptoms at high doses.
