BIOL 1F25 Lecture Notes - Lecture 10: Geographic Information System, Maneb, Herbicide
13 Feb 2017
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Formulated hypothesis: patients injected themselves with mppp or mptp, injection of mppp or mptp kills nerve cells in substantia nigra and causes symptoms of parkinson"s disease. Made testable predictions: prediction #1: if drug killed cells in substantia nigra that release dopamine, drugs that treat parkinson"s disease should relieve symptoms. Test the prediction: all 4 patients received l-dopa & carbidopa, all 4 patients showed some relief of symptoms at high doses. 1 patient experiencing side effects of l-dopa, so dose could not be increased. 1 patient removed from drugs after 2 months of treatment: reverted to complete immobility & rigidity. Formulated 2nd hypothesis: patients injected themselves with mppp or mptp and injection of mppp or mptp kills nerve cells in substantia nigra and causes symptoms of parkinson"s. Made a testable prediction prediction #2: if mppp or mptp caused parkinson-like symptoms in california patients, sample of the drug they took should contain mppp or mptp.
