BIOL 1F25 Lecture Notes - Lecture 3: Substantia Nigra, Mptp, Striatum
22 Sep 2016
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Occurs only after repeated testing that consistently supports the hypothesis over many conditions, usually by many researchers working independently. Theory is accepted as the best explanations for how things work in nature. Ohm"s law for electric circuits: voltage = current x resistance) 1982 - 4 drug addicts near san francisco developed sudden, severe symptoms of parkinson"s disease. They take shorter steps, often shuffling when trying to walk. Symptoms developed 4-14 days injecting new synthetic heroin (local dealer) All had history of heroin abuse (3 months to 14 years) 2 obtained new heroin in watsonville, mid-june. 2 obtained new heroin in san jose. Symptoms as severe as advanced parkinson"s disease (develops overtime) A graduate student synthesized his own synthetic heroin (mppp) and self-injected. Injected this for 4-6 months with no symptoms. Made shortcuts in synthesis; severe parkinson"s symptoms developed. After shortcut, drug contained a mixture of mppp and mptp (a byproduct of the chemical reaction)
