BIOL 1F25 Lecture 6: BIOL 1F25 MON SEPT 24 LEC

• School: Brock University
• Department: Biological Sciences
• Course: BIOL 1F25
• Professor: Joffre Mercier

Document Summary

Using the scientific method to study parkinson"s disease con"t. Scientific method: example langston et al. , 1983: blue circles are the cell body, arrows are terminal which dopamine"s is released from. Step 2: formulate hypothesis: patie(cid:374)ts i(cid:374) califor(cid:374)ia i(cid:374)je(cid:272)ted the(cid:373)sel(cid:448)es (cid:449)ith mppp or mptp and . If drug killed cells in substantia nigra that release dopamine, drugs that treat parkinson"s. Cerebrospinal fluid (csf) circulates through large spaces (ventricles) is continuous with interstitial fluid (fluid in small spaces between cells) Blood- brain barrier is selectively permeable: dopamine does not get through, related molecule (l-dopa) does get through, nerve cells that die in patients w parkinson"s are not replaced but filled with dopamine. L-dopa is (cid:862)pre(cid:272)ursor(cid:863) to dopa(cid:373)i(cid:374)e: (cid:374)euro(cid:374)s that (cid:373)ake dopa(cid:373)i(cid:374)e (cid:272)o(cid:374)(cid:448)ert l-dopa to dopamine. L-dopa has a carrier that will take it through the barrier. Strategy: restore dopamine levels in the brain how: dopamine is synthesized (produced) directly from l-dopa.