IMED3001 Final: IMED3001_ Hypertrophic Cardiomyopathy
9 Jan 2021
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Document Summary
Left ventricular hypertrophy of a non dilated chamber without an obvious cause such as hypertension or aortic stenosis. Prevalence: 1 in 500 of general population. Myocardial hypertrophy, abnormal diastolic filling and in 1/3 of cases intermittent ventricular outflow obstruction. Dynamic left ventricular outflow tract pressure gradient related to a narrowing of the subaortic area. Two diseases that must be distinguished clinically. Deposition diseases and hypertensive heart disease: pathogenesis: Heart does not fill properly due to increased thickness of ventricular wall. Mutations in any one of the genes that encode sarcomeric proteins. Mutations are found most commonly in the gene encoding . Marked hypertrophy of heart muscle without ventricular dilation. Ventricular cavity has a banana like configuration due to bulging of the septum into the lumen. May have endocardial thickening or mural thickening in outflow tract. Extensive hypertrophy of myocytes (up to 40 across) Double or triple apical precordial impulse, harsh systolic murmur, fourth heart sound.
