IMED3001 Lecture Notes - Lecture 22: Valvular Heart Disease, Aortic Insufficiency, Aortic Stenosis
26 Mar 2020
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In cardiac failure, actin and myosin don"t interact: some atrial cells have specific atrial granules in which anp is stored, valves: 4 cardiac valves, tricuspid and mitral valves (av) = Leaflets: aortic and pulmonary valves (sl)= cusps. Lad ca apex, anterior wall of lv, anterior 2/3 of iv septum. Well tolerated: pregnancy complicate valvular heart disease by increasing demand on heart, valvular stenosis leads to pressure overload of heart, valvular insufficiency leads to volume overload of heart. Injury to endocardium occur due to high speed jets of blood due to ejection through narrowed valves. Mitral incompetence: causes, myxoid degeneration (floppy valve) 5 . Intensity doesn"t change murmur radiates to the axilla. Ag of cardiac sarcolemma, myocardium, and valvular glycopeptides cause damage: antibodies against m proteins of streptococci can cross react with self- antigens in heart. Cd4+ t cells also react with self-proteins and produce cytokines: a connective tissue disorder characterised by fibrinoid necrosis, inflammation, fibrosis, pathognomonic feature, aschoff body:
