15 Jan 2022
Problem 7
Page 2768
Section: Review the Concepts
Chapter 17: Cell Organization and Movement I: Microfilaments
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15 Jan 2022
Background and context
The profilin–ATP–actin complex binds to the (+) end efficiently, and profilin dissociates once the new actin subunit is bound. This activity of profilin does not improve treadmilling pace on its own, but it does offer a source of ATP-actin from released ADP-actin; as a result, almost all free G-actin in a cell has bound ATP. As one might expect, the cell uses signal transduction pathways to regulate profilin and cofilin, and so actin filament turnover.
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