Missense mutations that have neutral effects
(a) frequently occur at the second codon position
(b) sometimes occur at the first codon position
(c) never change the amino acid sequence of the resulting peptide
(d) b and c
(e) a and b
Missense mutations that have neutral effects
(a) frequently occur at the second codon position
(b) sometimes occur at the first codon position
(c) never change the amino acid sequence of the resulting peptide
(d) b and c
(e) a and b
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Part B
Think about the DNA coding sequence of a gene. If an A were swapped for a T, what kind of mutation could it cause and why?
a) It could cause a frameshift nonsense or frameshift missense mutation because it would change the reading frame of the codon triplet. | ||||||||||||||||||||||||||||
b) It could cause a silent, missense, or nonsense mutation because those are the types that can be caused by a nucleotide-pair substitution like this one. | ||||||||||||||||||||||||||||
c) It could cause a nonsense mutation because the sequence would no longer be the same, so the protein would be shorter and non-functional. | ||||||||||||||||||||||||||||
d) It could cause a silent mutation because A and T are complementary to each other so it is not really a substitution mutation. Part C Why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide-pair substitution missense mutation in the same protein?
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